human leukocyte antigen-g (hla-g) and gastrointestinal malignancy

نویسندگان

ehsan nazemalhosseini-mojarad gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, iran

peter j.k. kuppen department of surgery, leiden university medical center, leiden, the netherlands

mohammad reza zali gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, iran

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Human Leukocyte antigen-G (HLA-G) and gastrointestinal malignancy

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Molecular pathways: human leukocyte antigen G (HLA-G).

Human leukocyte antigen G (HLA-G) is a nonclassical MHC class I molecule that exerts important tolerogenic functions. Its main physiologic expression occurs in the placenta, where it participates in the maternal tolerance toward the fetus. HLA-G expression was found in embryonic tissues, in adult immune privileged organs, and in cells of the hematopoietic lineage. It is expressed in various typ...

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Human Leukocyte Antigen-G (HLA-G) Polymorphism and Expression in Breast Cancer Patients

Human leukocyte antigen-G (HLA-G) is known to be implicated in a tumor-driven immune escape mechanism in malignancies. The purpose of this study was to investigate HLA-G polymorphism and expression in breast cancer. HLA-G alleles were determined by direct DNA sequencing procedures from blood samples of 80 breast cancer patients and 80 healthy controls. Soluble HLA-G (sHLA-G) was measured by enz...

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INTRODUCTION Sinonasal polyposis (NP) is a chronic inflammatory pathology of the nasal/paranasal cavities which affects from 1%-4% of the population. Although polyps seem to be a manifestation of chronic inflammation in both allergic and non-allergic subjects, the pathogenesis of nasal polyposis remains unknown. HLA-G molecules are a kind of no classic class I antigen with anti-inflammatory and...

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عنوان ژورنال:
gastroenterology and hepatology from bed to bench

جلد ۷، شماره ۲، صفحات ۲۰۱۴-۷

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